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Harry W. Kestler, PhD

Bruce Weigl PD

Dr. Harry W. Kestler,  Professor, Division of Math and Sciences, Lorain County Community College  

     Dr. Harry Kestler, the colorful LCCC professor and molecular biologist who created the first live attenuated vaccine for AIDS, is also credited with isolating the first pathogenic AIDS virus molecular clone and creating the "suicide" vaccine for AIDS. However, his students know him for his humor, value him as "mentor extraordinaire" and don't hesitate to drag him backstage after a performance of the indie rock band, American Toxic Event or to create a caricature of LCCC's "Micro-prof." The free AIDS testing offered on campus in December by his Microbiology class is an outgrowth of Kestler’s strong belief in the service component of learning along with his drive to increase AIDS awareness. 

A recording of Harry Kestler's February 26, 2014, presentationTraining the Next Generation of  Virus Hunters, is available for loan from the Bass Library.

 

          Born in Rochester, NY, Kestler received an A.S. in Psychology from Monroe Community College and then went on to receive a B.A in Psychology from the University of Rochester, where he graduated cum laude.  His academic appointments include that of Faculty at Harvard Medical School in the Department of Microbiology and Molecular Genetics, Adjunct Faculty at Clark University, Assistant Staff (Professor) at the Cleveland Clinic and faculty positions at Case Western Reserve University, Cleveland Clinic and Lorain County Community College.  He has focused on molecular biology and molecular virology, with an especial focus on AIDS.

          His teaching experience covers every age group from preschool to continuing education programs for physicians.  Of his 28 publications in peer reviewed journals, he has enjoyed either first or last authorship in such prestigious publications as Nature, Science, Cell and PNAS (Proceedings of the National Academy of Sciences). He also claims 58 published abstracts, 14 of which are related to projects that involved community college students -- 12 of whom were high school students.  All of these students have presented their results at national science meetings.  Hence, this writer's naming him "mentor extraordinaire."

 

                                                               

Publications

PUBLICATIONS:

 1.      Bedwell, D., Kestler, H., III, Davis, G., Gosink, M., Post, Ll, Nomura, M., Zengel, J.M., and Lindahl, L.  (1986)  Nucleotide sequence of the a ribosomal protein operon of E. coliN.A. 13(11): 3891-3903.

 2.      Kestler, H.W., III, Li, Y., Naidu, Y.M., Butler, C.V., Ochs, M.F., Jaenel, G., King, N.W., Daniel, M.D., and Desrosiers, R.C.  (1988)  Comparison of simian immunodeficiency virus isolatesNature 331: 619-621.

 3.      Daniel, M.D., Li, Y., Naidu, Y.M., Durda, P.J., Schmidt, D.K., Troup, C.D., Silva, D.P., MacKey, J.J., Kestler, H.W., III, Sehgal, P.K., King, N.W., Ohta, Y., Hayami, M., and Desrosiers, R.C.  (1988)  Simian immunodeficiency virus from African green monkeys.  J. Virol. 62: 4123-4128.

 4.      Naidu, Y.M., Kestler, H.W., III, Li, Y., Butler, C.V., Silva, D.P., Schmidt, D.K., Troup, C.D., Sehgal, P.K., Sonigo, P., Daniel, M.D., and Desrosiers, R.C.  (1988)  Characterization of infectious molecular clones of simian immunodeficiency virus (SIVmac) and human immunodeficiency virus type 2: persistent infection of rhesus monkeys with molecularly clones SIVmac.  J. Virol. 62: 4691-4969.

 5.      Desrosiers, R.C., Sehgal, P., Letvin, N., King, N., Ringler, D., Wyand, M., Naidu, Y., Kestler, H., Gritz, L., Mazzara, G., McKenzie, S., Panicali, D., and Daniel, M.D.  (1988)  SIV vaccine studies in rhesus monkeys.  In:  Retroviruses of Human A.I.D.S. and Related Animal Diseases, (M. Girard and L. Valette, Eds.), pg. 258-261.

 6.      Kestler, H.W., III, Naidu, Y.N., Kodama, T., King, N.W., Daniel, M.D., Li, Y., and Desrosiers, R.C.  (1989)  Use of infectious molecular clones of simian immunodeficiency virus for pathogenesis studies.  J. Med. Primatol. 18: 305-309.

 7.      Kodama, T., Wooley, D.P., Naidu, Y.M., Kestler, H.W., III, Daniel, M.D., Li, Y., and Desrosiers, R.C.  (1989)  The significance of premature stop codons in env of SIV.  J. virol. 63: 4709-4714.

 8.      Kestler, H,.W., III, Kodama, T., Burns, D.P.W., Ringler, D.J., King, N.W., Daniel, M.D., and Desrosiers, R.C.  (1989)  Nonhuman primate models for human lentivirus infection and their use in vaccine research.  Quantrieme Colloque Des Cent Gardes, pg. 287-292.

 9.      Kestler, H.W., III, Mori, K., Silva, D.P., Kodama, T., King, N.W., Daniel, M.D., and Desrosiers, R.C.  (1990)  Nef genes of SIV.  J. Med. Primatol. 19: 421-429.

 10.    Kodama, T., Burns, D.P.W., Kestler, H.W., III, Daniel, M.D., and Desrosiers, R.C.  (1990)  Molecular changes associated with replication of simian immunodeficiency virus in human cells.  J. Med. Primatol. 19: 431-437.

 11.    Kodama, T., Kestler, H.W., III, Burns, D.P.W., Ringler, D.J., King, N.W., Daniel, M.D., and Desrosiers, R.C.  (1990)  Nonhuman primate lentiviruses: models for human infection.  21st Congress of the IABS on progress in Animal Retroviruses, Annecy, France.  Develop. Biol. Standard, S. Karger, Basel, 72: 27-271.

 12.    Kestler, H., Kodama, T., Ringler, D., Marthas, M., Pedersen, N., Lackner, A., Regier, D., Sehgal, P., Daniel, M., King, N., and Desrosiers, R.  (1990)  Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virusScience 248: 1109-1112.

 13.    Burns, D.P.W., Kodama, T., Mori, K., Kestler, H.W., III, Morrison, H.G., Gibbs, J.S., Ringler, D.J., Daniel, M.D., and Desrosiers, R.C.  (1990)  Use of cloned SIVmac of defined sequence for the study of AIDS Pathogenesis.  SIV Vaccine Studies in Rhesus Monkeys.  In: Retroviruses of Human A.I.D.S. and Related Animal Diseases, (M. Girard and l. Valette, Eds.), pg. 47-52.

 14.    Kestler, H.W., III, Ringler, D.J., Mori, K., Panicali, D.L., Sehgal, P.K., Daniel, M.D., and Desrosiers, R.C.  (1991)  Importance of the nef gene for maintenance of high virus loads and for the development of AIDS.  Cell 191: 651-662.

 15.    Kirschhoff, F., Kestler, H.W., and Desrosiers, R.C.  (1994)  Upstream sequences in SIV are selectively deleted in vivo in the absence of nef function.  J. Virol. 68: 2031-2037.

 16.    Kestler, H.W., and Jeang, K.-T.  (1995)  The safety of a live attenuated vaccine for AIDSScience 270: 1218-1222.

 17.    Premkumar, D.R.D., Ma, X.-Z., Maitra, R.K., Chakrabarti, B.K., Salkowitz, J., Yen-Lieberman, B., Hirsch, M.S., and Kestler, H.W.  (1996)  The nef gene from a long-term HIV-1 nonprogressor.  AIDS Res. Human Retro. 12: 337-345.

 18.    Chakrabarti, B.K., Maitra, R.K., Ma, X.-Z., and Kestler, H.W.  (1996)  A live inactivatable attenuated vaccine for AIDS.  Proc. Natl. Acad. Sci. USA, 93:9810-9815.

19.    Salkowitz, J.R., Chakrabart, B.K., Yen-Lieberman, B., Starkey, C., Bendele, T., and Kestler, H.W.  (1996)  The nef gene of SIVmac239 is necessary for efficient growth in H9 cells.  J. Biomed. Sci., 3:422-434.

 20.    Kestler, H.W. and Chakrabarti, B.K.  (1997)  A live virus suicide vaccine for AIDS. Cleveland  Clinic Journal of Medicine  64:269-274.

 21.    Kestler, H.W.  1998  Animals and AIDS The encyclopedia  of , Ray A. Smith editor, Chicago: Fitzroy Dearborn Publishing

 22.    Ma, X.-Z., Maitra, R.K., Chakrabarti, B.K., Premkumar, D.R.D., Salkowitz, J., Yen-Lieberman, B., Gorensek, M., Hirsch, M.S., Calabrese, L., and Kestler, H.W.  (1996)  Naturally attenuated HIV.  J. Acquired Immune Deficency Syndromes and Human Retrovirology  

 23.    Salkowitz, J.R., Tobin, G., Ma, X.-Z., Gonda, M., Lairmore, M., and Kestler, H.W.  (1996)  Nef is sufficient for induction of disease in transgenic mice.  J. Acquired Immune Deficency Syndromes and Human Retrovirology  

 24.    Kestler, H.W.  1998  Retroviruses.  The encyclopedia  of AIDS, Ray A. Smith editor, Chicago: Fitzroy Dearborn Publishing

 25.    Kestler, H.W.  1998  HIV.  The encyclopedia  of AIDS, Ray A. Smith editor, Chicago: Fitzroy Dearborn Publishing .

 26.    Larsen, N. B., H. W. Kestler, et al. 1998. Mice transgenic for simian immunodeficiency virus nef are immunologically compromised. J Biomed Sci 5(4): 260-6.

 27.   Yoon, K., H. W. Kestler, et al. (1998). Growth properties of HSIVnef: HIV-1 containing the nef gene from pathogenic molecular clone SIVmac239. Virus Res 57(1): 27-34.

28.    Kestler, H.W.  Salkowitz, J.R.  and Trimble, J.T. (2000) “Animal models for AIDS”  in HIV:Molecular Mechanisms amd Clinical applications pp 479-513 Advances in Pharmacology Vol 49 Academic press, San Diego CA.  

Abstracts

ABSTRACTS:

 1.      Kestler, H., Zengel, J.M., and Lindahl, L.  (1984)  A novel regulation of R-protein synthesis from the alpha operon of E. coli.  Cold Spring Harbor Laboratory Bacteriophage Meeting, Cold Spring Harbor, New York.

 2.      Kestler, H.W., III, Li, Y., Naidu, Y.M., Daniel, M.D., and Desrosiers, R.C.  (1988)  Characterization of 3' ORF (NEF) mutants in molecular clones isolated at NERPRC.  6th Annual Symposium on Nonhuman Primate Models for AIDS.

 3.      Naidu, Y.M., Kestler, H.W., Li, Y., Daniel, M.D., and Desrosiers, R.C.  (1988)  Characterization of infectious molecular clones of SIVmac and HIV-2.  Cold Srping Harbor Laboratory RNA Tumor Viruses Meeting, Cold Spring Harbor, New York.

 4.      Li, Y., Naidu, Y.M., Durda, P.J., Kestler, H.W., Desrosiers, R.C., and Daniel, M.D.  (1988)  Simian immunodeficiency virus from African green monkeys.  Cold Srping Harbor Laboratory RNA Tumor Viruses Meeting, Cold Spring Harbor, New York.

 5.      Kestler, H.W., Li, Y., Naidu, Y.M., Butler, C.V., Ochs, M.F., Jaenel, G., King, N.W., Daniel, M.D., and Desrosiers, R.C.  (1988)  Comparison of Simian immunodeficiency virus isolates.  Cold Srping Harbor Laboratory RNA Tumor Viruses Meeting, Cold Spring Harbor, New York.

 6.      Kestler, H.W., Stallard, V., Mazzara, G., Panicalli, D., Li, Y., Daniel, M.D., and Desrosiers, R.C.  (1989)  Mutagenic analysis of NEF genes from SIV.  7th Annual Symposium on Nonhuman Primate Models for AIDS, Portland, Oregon.

 7.      Kodama, T., Wooley, D., Kestler, H., Daniel, M., Li, Y., and Desorisers, R.  (1989)  The significance of premature stop codons in env of SIV.  7th Annual Symposium on Nonhuman Primate Models for AIDS, Portland, Oregon.

 8.      Kestler, H.W., Li, Y., Daniel, M.D., Butler, C.V., and Desrosiers, R.C.  (1989)  Characterization of nef genes from SIV and HIV-2.  V International Conference on AIDS, Montreal, Quebec, Canada.

 9.      Hattori, N., Gartner, S., Fargnoli, K., Popovic, M., Wong-Staal, F., Kestler, H., Desrosier, R., Gallo, R.C., and Franchini, G.  1989.  The NEF gene of HIV-2 is not required for infectivity and replication of primary human macrophages.  Cold Spring Harbor Laboratory RNA Tumor Viruses Meeting, Cold Spring Harbor, New York.

 10.    Kestler, H.W., Li, Y., Kodama, T., Butler, C.V., Daniel, M.D., and Desrosiers, R.C.  (1989)  Characterization of NEF genes from SIV and HIV-2.  Cold Spring Harbor Laboratory RNA Tumor Viruses Meeting, Cold Spring Harbor, New York.

 11.    Li, Y., Naidu, Y.M., Kestler, H.W., Fultz, P., Daniel, M.D., and Desrosiers, R.C.  (1990)  SIVsmm, a possible progenitor of HIV-2 and SIVmac.  Cold Spring Harbor Laboratory RNA Tumor Viruses Meeting, Cold Spring Harbor, New York.

 12.    Kodama, T., Naidu, Y., Wooley, D., Kestler, H., Li, Y., and Desrosiers, R.  (1990)  The significance of premature stop codons in env of SIV.  Cold Spring Harbor Laboratory RNA Tumor Viruses Meeting, Cold Spring Harbor, New York.

 13.    Kestler, H., Regier, D., Mori, K., Kodama, T., Daniel, M., and Desrosiers, R.  (1990)  Nucleotide sequence of the pathogenic SIV239 clone analysis of nef function.  8th Annual Symposium on Nonhuman Primate Models for AIDS, New Orleans, Louisiana.

 14.    Kestler, H., Regier, D., Mori, K., Kodama, T., Daniel, M., and Desrosiers, R.  (1990)  Nucleotide sequence of the pathogenic SIV239 clone and analysis of nef function.  Cold Srping Harbor Laboratory RNA Tumor Viruses Meeting, Cold Spring Harbor, New York.

 15.    Kestler, H.W., Ringler, D.J., Mori, K., Daniel, M.D., and Desrosiers, R.C.  (1991)  The significance of the nef gene in the maintenance of high virus loads and for the development of AIDS.  Cold Srping Harbor Laboratory RNA Tumor Viruses Meeting, Cold Spring Harbor, New York.

 16.    Premkumar, D., Salkowitz, J., Hirsch, M., and Kestler, H.W.  (1992)  Structure of nef genes of long-term survivors of HIV-1 infection.  CCF Research Day.

 17.    Salkowitz, J., Premkumar, D., and Kestler, H.W.  (1992)  The molecular basis of Simian immunodeficiency virus NEF function.  CCF Research Day.

 18.    Premkumar, D., Salkowitz, J., Hirsch, M., and Kestler, H.W.  (1992)  Structure of nef genes of long-term survivors of HIV-1 infection.  10th Annual Symposium of Non-Human Primate Models for AIDS.

 19.    Salkowitz, J., Premkumar, D., and Kestler, H.W.  (1992)  The molecular basis of Simian immunodeficiency virus NEF function.  10th Annual Symposium of Non-Human Primate Models for AIDS.

 20.    Kestler, H.W., Salkowitz, J., and Premkumar, D.  (1993)  The molecular basis of nef  function: The positive effect of a "negative factor".  Keystone Symposia Meeting, "Frontiers in HIV Pathogenesis", Albuquerque, NM.

 21.    Salkowitz, J.R., Premkumar, D.R.D., and Kestler, H.W.  (1993)  SIVmac239 nef is a potent down-modulator of human CD4.  Retrovirus Meeting, Cold Spring Harbor Laboratories, Cold Spring Harbor, NY.

 22.    Salkowitz, J., and Kestler, H.W.  (1993)  CD4 down-modulation can be induced by both non-pathogenic and pathogenic SIV nef alleles.  The Cleveland Clinic Foundation, Research Day.

 23.    Salkowitz, J., and Kestler, H.W.  (1993)  CD4 down-modulation can be induced by both non-pathogenic and pathogenic Simian Immunodeficiency Virus nef alleles.  American Society of Microbiology, First National Conference on Human Retroviruses and Related Infectious Diseases, Washington, DC.

 24.    Kestler, H.W.  (1994)  The role of nef in the pathogenesis of primate lentiviruses.  Keystone Symposium, Prevention and Treatment of AIDS, Hilton Head, SC.

 25.    Kestler, H.W., Premkumar, D., Salkowitz, J.R., and Chakrabarti, B.K.  (1994)  The unique nature of nef quasispecies from a long-term survivor of HIV infection: Implications for function/comparison with other isolates.  The Cleveland Clinic Foundation 14th Annual Research Day, Cleveland, OH.

 26.    Salkowitz, J.R., and Kestler, H.W.  (1994)  CD4 down-modulation can be induced by both non-pathogenic and pathogenic SIV nef alleles.  The Cleveland Clinic Foundation 14th Annual Research Day, Cleveland, OH.

 27.    Salkowtiz, J.R., Chakrabarti, B., and Kestler, H.W.  (1994)  CD4 down-modulation can be induced by both non pathogenic and pathogenic SIVnef alleles.  12th Annual Symposium on Nonhuman Primate Models for AIDS.  Boston, MA.

 28.    Kestler, H.W.  (1995)  Nef gene from long-term survivors of HIV infection.  Keystone Symposium, Invited Speaker.  Silverthorne, CO.

 29.    Kestler, H.W., Premkumar, D., Salkowitz, J.R., and Chakrabarti, B.K.  The unique nature of the nef gene from a long-term survivor of HIV infection.  (1995)  2nd National Conference on Human Retroviruses and Related Infections.  Washington, DC.

 30.    Yoon, K.J., Kang, M.R., Lee, H.Y., Kestler, H.W., and Kim, S.  (1995)  Growth properties of HSIV nef-HIV-1 containing the nef gene from pathogenic molecular clone SIVmac239.  Cold Spring Harbar Retrovirus Meeting.  Cold Spring Harbor, NY.

 31.    Chakrabarti, B.K., Matira, R., and Kestler, H.W.  (1995)  A live inactivatable attenuated vaccine for AIDS.  Cold Spring Harbar Retrovirus Meeting.  Cold Spring Harbor, NY.

 32.    Kestler, H.W., Chakrabarti, B.K., and Salkowitz, J.R.  (1995)  CD4 down-modulation can be induced by both nonpathogenic and pathogenic SIV nef alleles.  Cold Spring Harbar Retrovirus Meeting.  Cold Spring Harbor, NY.

 33.    Kestler, H.W., Ma, X.-Z., Matra, R., Premkumar, D., Salkowitz, J.R., and Chakrabarti, B.K.  (1995)  Nef quasispecies from long-term surviviros of HIV infection:  Comparison with other isolates.  Cold Spring Harbar Retrovirus Meeting.  Cold Spring Harbor, NY.

 34.    Kestler, H.W., Gonda, M., Tobin, G., Larsen, N., Docherty, J.J., and Salkowitz, J.R.  (1995)  Nef is sufficient for induction of disease in transgenic mice.  15th Annual CCF Research Day.  Cleveland, Ohio.

 35.    Chakrabarti, B.K., Maitra, R.K., and Kestler, H.W.  (1995)  A live inactivatable attenuated vaccine for AIDS.  15th Annual CCF Research Day.  Cleveland, Ohio.

 36.    Ma, X.-Z., Maitra, R.K., Chakrabarti, B., and Kestler, H.W.  (1995)  Naturally attenuated HIV.  15th Annual CCF Research Day, Cleveland, Ohio.

 37.    Kestler, H.W., Maitra, R.K., and Chakrabarti, B.K.  (1996)  A live attenuated inactivatable vaccine for AIDS.  Keystone Symposium.  Taos, New Mexico.

 38.    Chakrabarti, B.K., Maitra, R.K., Ma, X.-Z., and Kestler, H.W.  (1996)  A candidate live inactivatable attenuated vaccine for AIDS.  Institute of Human Virology Annual Meeting, Baltimore, Maryland.

 39.    Ma, X.-Z., Maitra, R.K., Chakrabarti, B.K., Premkumar, D.R.D., Salkowitz, J., Yen-Lieberman, B., Gorensek, M., Hirsch, M.S., Calabrese, L., and Kestler, H.W.  (1996)  Naturally attenuated HIV.   Institute of Human Virology Annual Meeting, Baltimore, Maryland.

 40.    Salkowitz, J.R., Tobin, G., Ma, X.-Z., Gonda, M., Lairmore, M., and Kestler, H.W.  (1996)  Nef is sufficient for induction of disease in transgenic mice.   Institute of Human Virology Annual Meeting, Baltimore, Maryland.

 41.    Gorensek, M., Ma, X.-Z., Yen-Lieberman, B., Munger, P., Reyes, R.R., Halldorsdottier, K. and Kestler, H.W. (1996) A Study of an HIV-infected Long Term Non-Progressor and Her Four Infected Children. ICAAC Annual meeting, New Orleans

 42.          Larsen, N., Tobin, G., Salkowitz, J.R., Ma, X.-Z., Gonda, M., Docherty, J.J., and Kestler, H.W.,  (1996) Imunologic Function of Mice Transgenic for SIV NEF School of Biomedical Sciences Annual Meeting, Kent State University, Kent, Ohio.

 43.          Salkowitz, J.R., & Kestler, H.W.,(1999) SIVmac239 nef is Sufficient for Induction of Disease in Transgenic Mice.  Sixth Annual Conference on Retroviruses and Opportunistic Infections. Chicago Ill.

 44.          Styfurak, L.M., Hogan, K.D., Crooks, J.R., Kestler, H.W., & Miller, A.C.  (2004) Antibiotic Resistance at A Newly Restored Wetlands. Annual meeting of the American Association for the Advancement of Science, Seattle WA

 45.          Styfurak, L.M., Hogan, K.D., Pope M.,Miller, A.C., & Kestler, H.W.  (2005) Antibiotic Resistance at A Newly Restored Wetlands. Annual meeting of the American Association for the Advancement of Science Washington D.C.

 46.          Shuman, D., Camp, M., Jenkins, J., Sedley, J., DeVries, J., Morris, R., Ashwathnarayana, N., Nagisetty, J  & Kestler, H.W (2009) Analysis Of The HIV Co-Receptor CCR5 Gene From An African-American Family. Sigma Xi Annual Meeting & International Research Conference The Woodlands, Texas

47.          Shuman, D., Camp, M., Jenkins, J, DeVries, J., Morris, R., & Kestler, H.W (2010) Analysis Of The HIV Co-Receptor CCR5 Gene From An African-American Family. American Association for the Advancement of Science Annual Meeting, San Deigo CA

 

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